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  <xs:element id="ddog_ScenarioTwoMember" abstract="true" name="ScenarioTwoMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_ScenarioThreeMember" abstract="true" name="ScenarioThreeMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_DebtInstrumentConvertibleMeasurementPeriod" abstract="false" name="DebtInstrumentConvertibleMeasurementPeriod" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ddog_DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" abstract="false" name="DebtInstrumentPrincipalAmountDenominationForConversionIntoCommonStock" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_DebtInstrumentConvertibleThresholdMaximumPercentageOfProductOfLastReportedSalePriceOfCommonStock" abstract="false" name="DebtInstrumentConvertibleThresholdMaximumPercentageOfProductOfLastReportedSalePriceOfCommonStock" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="ddog_PaymentOrRetirementOfDebtIssuanceCosts" abstract="false" name="PaymentOrRetirementOfDebtIssuanceCosts" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_AdjustmentsToAdditionalPaidInCapitalRetirementOfConvertibleDebt" abstract="false" name="AdjustmentsToAdditionalPaidInCapitalRetirementOfConvertibleDebt" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_TerminationAgreementAmount" abstract="false" name="TerminationAgreementAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_IncreaseInAdjustmentsToAdditionalPaidInCapital" abstract="false" name="IncreaseInAdjustmentsToAdditionalPaidInCapital" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_CappedCallTerminationNetCashPayments" abstract="false" name="CappedCallTerminationNetCashPayments" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_ConvertibleSeniorNotesDue2025And2029Member" abstract="true" name="ConvertibleSeniorNotesDue2025And2029Member" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_InitialCapPricePerShareOfCappedCalls" abstract="false" name="InitialCapPricePerShareOfCappedCalls" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:perShareItemType"/>
  <xs:element id="ddog_CostIncurredToPurchaseCappedCalls" abstract="false" name="CostIncurredToPurchaseCappedCalls" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_CommonStockCoveredUnderCappedCallsTransaction" abstract="false" name="CommonStockCoveredUnderCappedCallsTransaction" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ddog_LongTermDebtPrincipalAndFutureInterestPayment" abstract="false" name="LongTermDebtPrincipalAndFutureInterestPayment" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_LesseeOperatingLeaseTerminationTerm" abstract="false" name="LesseeOperatingLeaseTerminationTerm" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:durationItemType"/>
  <xs:element id="ddog_OperatingLeaseNonCashLeaseExpense" abstract="false" name="OperatingLeaseNonCashLeaseExpense" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_InternationalMember" abstract="true" name="InternationalMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_A2012EquityIncentivePlanMember" abstract="true" name="A2012EquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_TwoThousandNineteenEquityIncentivePlanMember" abstract="true" name="TwoThousandNineteenEquityIncentivePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_EmployeeStockPurchasePlanMember" abstract="true" name="EmployeeStockPurchasePlanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_RestrictedStockUnitsAndRestrictedStockMember" abstract="true" name="RestrictedStockUnitsAndRestrictedStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_NumberOfCommonStockClasses" abstract="false" name="NumberOfCommonStockClasses" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ddog_NumberOfVotingRightsEntitledToStockholdersPerShare" abstract="false" name="NumberOfVotingRightsEntitledToStockholdersPerShare" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ddog_ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquityIncentivePlan" abstract="false" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardNumberOfEquityIncentivePlan" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:integerItemType"/>
  <xs:element id="ddog_CommonStockIssuableUponExerciseOfOptionsOutstandingShares" abstract="false" name="CommonStockIssuableUponExerciseOfOptionsOutstandingShares" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ddog_EmployeeStockOptionRestrictedStockUnitsAndPerformanceStockUnitsMember" abstract="true" name="EmployeeStockOptionRestrictedStockUnitsAndPerformanceStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_SharesAvailableForFutureGrantsMember" abstract="true" name="SharesAvailableForFutureGrantsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueAbstract" abstract="true" name="ShareBasedCompensationArrangementByShareBasedPaymentAwardOptionsOutstandingAggregateIntrinsicValueAbstract" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:stringItemType"/>
  <xs:element id="ddog_RestrictedStockUnitsRestrictedStockAwardsAndPerformanceStockUnitsMember" abstract="true" name="RestrictedStockUnitsRestrictedStockAwardsAndPerformanceStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_PercentageOfNetOperatingLossCarryforwardsSubjectedToTaxableIncomeLimitation" abstract="false" name="PercentageOfNetOperatingLossCarryforwardsSubjectedToTaxableIncomeLimitation" nillable="true" xbrli:periodType="instant" substitutionGroup="xbrli:item" type="dtr-types1:percentItemType"/>
  <xs:element id="ddog_IncomeTaxReconciliationUncertainTaxPositions" abstract="false" name="IncomeTaxReconciliationUncertainTaxPositions" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_EffectiveIncomeTaxRateReconciliationCompensationLimitAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationCompensationLimitAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_EffectiveIncomeTaxRateReconciliationReturnToProvisionAmount" abstract="false" name="EffectiveIncomeTaxRateReconciliationReturnToProvisionAmount" nillable="true" xbrli:periodType="duration" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_DeferredTaxAssetsCapitalization" abstract="false" name="DeferredTaxAssetsCapitalization" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_DeferredTaxAssetsLeaseLiability" abstract="false" name="DeferredTaxAssetsLeaseLiability" nillable="true" xbrli:periodType="instant" xbrli:balance="debit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_DeferredTaxLiabilitiesCommissions" abstract="false" name="DeferredTaxLiabilitiesCommissions" nillable="true" xbrli:periodType="instant" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_ReallocationOfUndistributedIncomeLossResultOfConversionOfCommonStock" abstract="false" name="ReallocationOfUndistributedIncomeLossResultOfConversionOfCommonStock" nillable="true" xbrli:periodType="duration" xbrli:balance="credit" substitutionGroup="xbrli:item" type="xbrli:monetaryItemType"/>
  <xs:element id="ddog_WeightedAverageNumberDilutedSharesOutstandingConversionOfCommonSharesClass" abstract="false" name="WeightedAverageNumberDilutedSharesOutstandingConversionOfCommonSharesClass" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="xbrli:sharesItemType"/>
  <xs:element id="ddog_EmployeeStockOptionAndRestrictedStockUnitsMember" abstract="true" name="EmployeeStockOptionAndRestrictedStockUnitsMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_UnvestedEarlyExercisedStockOptionsAndRestrictedStockMember" abstract="true" name="UnvestedEarlyExercisedStockOptionsAndRestrictedStockMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_SharesIssuableUponConversionOfThe2025NotesMember" abstract="true" name="SharesIssuableUponConversionOfThe2025NotesMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types1:domainItemType"/>
  <xs:element id="ddog_SeanWaltersMember" abstract="true" name="SeanWaltersMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_DavidObstlerMember" abstract="true" name="DavidObstlerMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_MichaelCallahanMember" abstract="true" name="MichaelCallahanMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
  <xs:element id="ddog_KerryAcocellaMember" abstract="true" name="KerryAcocellaMember" nillable="true" xbrli:periodType="duration" substitutionGroup="xbrli:item" type="dtr-types:domainItemType"/>
</xs:schema>
